{"id":3562,"date":"2025-06-02T08:54:11","date_gmt":"2025-06-02T06:54:11","guid":{"rendered":"https:\/\/remeds.org\/?p=3562"},"modified":"2025-11-14T09:26:07","modified_gmt":"2025-11-14T08:26:07","slug":"umass-licenses-sirna-mecp2-duplication-syndrome","status":"publish","type":"post","link":"https:\/\/remeds.org\/fr\/2025\/06\/02\/umass-licenses-sirna-mecp2-duplication-syndrome\/","title":{"rendered":"Une nouvelle avanc\u00e9e dans la recherche d'un rem\u00e8de : l'UMass Chan octroie une licence pour la technologie siRNA \u00a0"},"content":{"rendered":"<p class=\"wp-block-paragraph\">L'\u00e9cole de m\u00e9decine UMass Chan a octroy\u00e9 une licence pour une technologie prometteuse bas\u00e9e sur le siRNA \u00e0 M2DS, une start-up visant \u00e0 faire progresser cette technologie en tant que traitement du syndrome de duplication du g\u00e8ne MECP2. Cela marque une avanc\u00e9e majeure dans la poursuite vers une application clinique.<a href=\"https:\/\/dupmecp2.eu\/recruitement-hero\/\"><\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Cette technologie a \u00e9t\u00e9 d\u00e9velopp\u00e9e dans le laboratoire du Dr Khvorova, sous la direction de Vignesh Hariharan. Les premi\u00e8res recherches ont \u00e9t\u00e9 men\u00e9es gr\u00e2ce au financement de Cure MDS et du Rett Syndrome Research Trust. Ce siRNA agit en ciblant et en d\u00e9gradant l'ARN messager responsable de la surproduction de la prot\u00e9ine MeCP2. <\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Dans les \u00e9tudes men\u00e9es sur des souris, une dose de ce compos\u00e9 a atteint efficacement le cerveau et la moelle \u00e9pini\u00e8re et ne n\u00e9cessiterait qu'une ou deux administrations par an. Gr\u00e2ce \u00e0 l'octroi d'une licence pour cette technologie \u00e0 M2DS, le candidat m\u00e9dicament entre d\u00e9sormais dans une phase o\u00f9 il peut b\u00e9n\u00e9ficier du soutien n\u00e9cessaire progresser vers des essais cliniques sur l'homme. <\/p>\n\n\n\n<p class=\"wp-block-paragraph\">En plus des essais cliniques en cours men\u00e9s par Ionis et HuidaGene, cette avanc\u00e9e majeure pourrait constituer un ajout prometteur \u00e0 la liste des traitements potentiels pour cette maladie rare et complexe.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><a href=\"https:\/\/bridge.umassmed.edu\/s\/news\/news-article\/umass-chan-licenses-sirna-therapeutics-for-mecp2-duplication-syndrome-MCMWKNCJYQ25CQHF5YITTOM757HU\">Voir le communiqu\u00e9 de presse<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>","protected":false},"excerpt":{"rendered":"<p>UMass Chan Medical School has licensed a promising siRNA-based technology to M2DS, a startup company dedicated to advancing the technology as a treatment for MECP2 Duplication Syndrome. This marks a major step forward in translating cutting-edge research into clinical reality. The technology was developed in the lab of Dr. Khvorova, with the project led by [&hellip;]<\/p>\n","protected":false},"author":114,"featured_media":3563,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_jf_save_progress":"","footnotes":""},"categories":[9,24],"tags":[],"class_list":["post-3562","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-research","category-sirna"],"_links":{"self":[{"href":"https:\/\/remeds.org\/fr\/wp-json\/wp\/v2\/posts\/3562","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/remeds.org\/fr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/remeds.org\/fr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/remeds.org\/fr\/wp-json\/wp\/v2\/users\/114"}],"replies":[{"embeddable":true,"href":"https:\/\/remeds.org\/fr\/wp-json\/wp\/v2\/comments?post=3562"}],"version-history":[{"count":3,"href":"https:\/\/remeds.org\/fr\/wp-json\/wp\/v2\/posts\/3562\/revisions"}],"predecessor-version":[{"id":3567,"href":"https:\/\/remeds.org\/fr\/wp-json\/wp\/v2\/posts\/3562\/revisions\/3567"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/remeds.org\/fr\/wp-json\/wp\/v2\/media\/3563"}],"wp:attachment":[{"href":"https:\/\/remeds.org\/fr\/wp-json\/wp\/v2\/media?parent=3562"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/remeds.org\/fr\/wp-json\/wp\/v2\/categories?post=3562"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/remeds.org\/fr\/wp-json\/wp\/v2\/tags?post=3562"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}