{"id":1400,"date":"2024-08-29T17:27:57","date_gmt":"2024-08-29T15:27:57","guid":{"rendered":"https:\/\/remeds.org\/?p=1400"},"modified":"2025-02-06T17:36:55","modified_gmt":"2025-02-06T16:36:55","slug":"ion440-%cf%84%ce%bf-ionis-%cf%86%ce%ad%cf%81%ce%bd%ce%b5%ce%b9-%cf%84%ce%b7%ce%bd-%ce%ba%ce%bf%ce%b9%ce%bd%cf%8c%cf%84%ce%b7%cf%84%ce%b1-mds-%cf%83%cf%84%ce%bf-%ce%b5%cf%80%cf%8c%ce%bc%ce%b5%ce%bd","status":"publish","type":"post","link":"https:\/\/remeds.org\/el\/2024\/08\/29\/ion440-ionis-brings-mds-community-to-the-next-level\/","title":{"rendered":"ION440: IONIS \u03c6\u03ad\u03c1\u03bd\u03b5\u03b9 \u03c4\u03b7\u03bd \u03ba\u03bf\u03b9\u03bd\u03cc\u03c4\u03b7\u03c4\u03b1 MDS \u03c3\u03c4\u03bf \u03b5\u03c0\u03cc\u03bc\u03b5\u03bd\u03bf \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03bf"},"content":{"rendered":"<p class=\"wp-block-paragraph\">\u03a3\u03c5\u03bd\u03c4\u03ac\u03c7\u03b8\u03b7\u03ba\u03b5 \u03b1\u03c0\u03bf \u03c4\u03bf\u03bd David \u03ba\u03b1\u03b9 \u03b5\u03c0\u03b1\u03bb\u03b7\u03b8\u03b5\u03cd\u03c4\u03b7\u03ba\u03b5 \u03b1\u03c0\u03bf \u03c4\u03bf\u03bd Ionis<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<p class=\"wp-block-paragraph\">\u039c\u03b5\u03c4\u03ac \u03c4\u03b7\u03bd \u03c0\u03c1\u03cc\u03c3\u03c6\u03b1\u03c4\u03b7 \u03b1\u03bd\u03b1\u03ba\u03bf\u03af\u03bd\u03c9\u03c3\u03b7 \u03c4\u03b7\u03c2 Ionis \u03c3\u03c7\u03b5\u03c4\u03b9\u03ba\u03ac \u03bc\u03b5 \u03c4\u03b7\u03bd \u03b5\u03c0\u03b5\u03c1\u03c7\u03cc\u03bc\u03b5\u03bd\u03b7 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03b4\u03bf\u03ba\u03b9\u03bc\u03ae, \u03c3\u03ba\u03bf\u03c0\u03b5\u03cd\u03bf\u03c5\u03bc\u03b5 \u03bd\u03b1 \u03c0\u03b1\u03c1\u03ac\u03c3\u03c7\u03bf\u03c5\u03bc\u03b5 \u03bc\u03b9\u03b1 \u03c3\u03b1\u03c6\u03ad\u03c3\u03c4\u03b5\u03c1\u03b7 \u03ba\u03b1\u03c4\u03b1\u03bd\u03cc\u03b7\u03c3\u03b7 \u03b1\u03c5\u03c4\u03ae\u03c2 \u03c4\u03b7\u03c2 \u03b4\u03bf\u03ba\u03b9\u03bc\u03ae\u03c2. \u0395\u03af\u03bd\u03b1\u03b9 \u03b9\u03b4\u03b9\u03b1\u03af\u03c4\u03b5\u03c1\u03b1 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03cc \u03b3\u03b9\u03b1 \u03c4\u03b9\u03c2 \u03bf\u03b9\u03ba\u03bf\u03b3\u03ad\u03bd\u03b5\u03b9\u03b5\u03c2 \u03c0\u03bf\u03c5 \u03c3\u03ba\u03ad\u03c6\u03c4\u03bf\u03bd\u03c4\u03b1\u03b9 \u03bd\u03b1 \u03b5\u03b3\u03b3\u03c1\u03ac\u03c8\u03bf\u03c5\u03bd \u03c4\u03bf \u03c0\u03b1\u03b9\u03b4\u03af \u03c4\u03bf\u03c5\u03c2 \u03bd\u03b1 \u03b3\u03bd\u03c9\u03c1\u03af\u03b6\u03bf\u03c5\u03bd \u03c4\u03b9 \u03b5\u03af\u03bd\u03b1\u03b9 \u03bc\u03b9\u03b1 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03b4\u03bf\u03ba\u03b9\u03bc\u03ae, \u03b9\u03b4\u03af\u03c9\u03c2 \u03c3\u03c4\u03bf \u03c0\u03bb\u03b1\u03af\u03c3\u03b9\u03bf \u03c3\u03c0\u03ac\u03bd\u03b9\u03c9\u03bd \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03b9\u03ce\u03bd \u03cc\u03c0\u03c9\u03c2 \u03c4\u03bf \u03c3\u03cd\u03bd\u03b4\u03c1\u03bf\u03bc\u03bf \u03b4\u03b9\u03c0\u03bb\u03b1\u03c3\u03b9\u03b1\u03c3\u03bc\u03bf\u03cd MECP2 (MDS).<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u039c\u03b9\u03b1 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03b4\u03bf\u03ba\u03b9\u03bc\u03ae \u03b5\u03af\u03bd\u03b1\u03b9 \u03bc\u03b9\u03b1 \u03b5\u03c1\u03b5\u03c5\u03bd\u03b7\u03c4\u03b9\u03ba\u03ae \u03bc\u03b5\u03bb\u03ad\u03c4\u03b7 \u03c0\u03bf\u03c5 \u03b4\u03b9\u03b5\u03c1\u03b5\u03c5\u03bd\u03ac \u03bd\u03ad\u03b5\u03c2 \u03c0\u03b9\u03b8\u03b1\u03bd\u03ad\u03c2 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b5\u03c2, \u03b1\u03be\u03b9\u03bf\u03bb\u03bf\u03b3\u03ce\u03bd\u03c4\u03b1\u03c2 \u03c4\u03b7\u03bd \u03b1\u03c3\u03c6\u03ac\u03bb\u03b5\u03b9\u03b1 \u03ba\u03b1\u03b9 \u03c4\u03b9\u03c2 \u03b5\u03c0\u03b9\u03c0\u03c4\u03ce\u03c3\u03b5\u03b9\u03c2 \u03c4\u03bf\u03c5\u03c2 \u03c3\u03c4\u03bf\u03bd \u03ac\u03bd\u03b8\u03c1\u03c9\u03c0\u03bf. \u039f\u03b9 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ad\u03c2 \u03b4\u03bf\u03ba\u03b9\u03bc\u03ad\u03c2 \u03b4\u03b9\u03b5\u03be\u03ac\u03b3\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c3\u03c5\u03c7\u03bd\u03ac \u03c3\u03c4\u03bf \u03c0\u03bb\u03b1\u03af\u03c3\u03b9\u03bf \u03b5\u03bd\u03cc\u03c2 \u03b5\u03c5\u03c1\u03cd\u03c4\u03b5\u03c1\u03bf\u03c5 \u03c0\u03c1\u03bf\u03b3\u03c1\u03ac\u03bc\u03bc\u03b1\u03c4\u03bf\u03c2 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae\u03c2 \u03b1\u03bd\u03ac\u03c0\u03c4\u03c5\u03be\u03b7\u03c2. \u0388\u03bd\u03b1 \u03c0\u03c1\u03cc\u03b3\u03c1\u03b1\u03bc\u03bc\u03b1 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae\u03c2 \u03b1\u03bd\u03ac\u03c0\u03c4\u03c5\u03be\u03b7\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03bc\u03b9\u03b1 \u03c3\u03b5\u03b9\u03c1\u03ac \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ce\u03bd \u03b4\u03bf\u03ba\u03b9\u03bc\u03ce\u03bd \u03c0\u03bf\u03c5 \u03b4\u03b9\u03b5\u03be\u03ac\u03b3\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c3\u03b5 \u03c0\u03c1\u03bf\u03bf\u03b4\u03b5\u03c5\u03c4\u03b9\u03ba\u03ad\u03c2 \u03c6\u03ac\u03c3\u03b5\u03b9\u03c2 (\u03c0.\u03c7. \u03a6\u03ac\u03c3\u03b7 1-3) \u03ba\u03b1\u03b9 \u03b1\u03c0\u03bf\u03c3\u03ba\u03bf\u03c0\u03bf\u03cd\u03bd \u03c3\u03c4\u03bf \u03bd\u03b1 \u03ba\u03b1\u03b8\u03bf\u03c1\u03af\u03c3\u03bf\u03c5\u03bd \u03ba\u03b1\u03c4\u03ac \u03c0\u03cc\u03c3\u03bf\u03bd \u03c4\u03b1 \u03bd\u03ad\u03b1 \u03b4\u03c5\u03bd\u03b7\u03c4\u03b9\u03ba\u03ac \u03c6\u03ac\u03c1\u03bc\u03b1\u03ba\u03b1 \u03ae \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b5\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b5\u03c0\u03b1\u03c1\u03ba\u03ce\u03c2 \u03b1\u03c3\u03c6\u03b1\u03bb\u03ae \u03ba\u03b1\u03b9 \u03bf\u03c5\u03c3\u03b9\u03b1\u03c3\u03c4\u03b9\u03ba\u03ac \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03c3\u03bc\u03b1\u03c4\u03b9\u03ba\u03ac.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u03a3\u03c4\u03b7\u03bd \u03c0\u03b5\u03c1\u03af\u03c0\u03c4\u03c9\u03c3\u03b7 \u03c4\u03bf\u03c5 MDS, \u03b7 Ionis \u03b8\u03b1 \u03be\u03b5\u03ba\u03b9\u03bd\u03ae\u03c3\u03b5\u03b9 \u03c3\u03cd\u03bd\u03c4\u03bf\u03bc\u03b1 \u03bc\u03b9\u03b1 \u03c0\u03c1\u03ce\u03c4\u03b7 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03b4\u03bf\u03ba\u03b9\u03bc\u03ae \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd \u03b1\u03be\u03b9\u03bf\u03bb\u03cc\u03b3\u03b7\u03c3\u03b7 \u03bc\u03b9\u03b1\u03c2 \u03bd\u03ad\u03b1\u03c2 \u03b4\u03c5\u03bd\u03b7\u03c4\u03b9\u03ba\u03ae\u03c2 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1\u03c2 \u03bc\u03b5 \u03c4\u03b7\u03bd \u03bf\u03bd\u03bf\u03bc\u03b1\u03c3\u03af\u03b1 ION440. \u0397 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b7 \u03b1\u03c5\u03c4\u03ae, \u03bc\u03b5 \u03c4\u03b7\u03bd \u03bf\u03bd\u03bf\u03bc\u03b1\u03c3\u03af\u03b1 ATTUNE, \u03b1\u03bd\u03b1\u03ba\u03bf\u03b9\u03bd\u03ce\u03b8\u03b7\u03ba\u03b5 \u03c0\u03c1\u03cc\u03c3\u03c6\u03b1\u03c4\u03b1 \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd Ionis \u03c3\u03c4\u03bf clinicaltrials.gov \u03bc\u03b5 \u03c4\u03bf\u03bd \u03b5\u03c0\u03af\u03c3\u03b7\u03bc\u03bf \u03c4\u03af\u03c4\u03bb\u03bf \u03c4\u03b7\u03c2 \"A Phase 1-2, Double-Blind, Sham-Controlled Multiple Ascending Dose Study to Evaluate Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Intrathecally-Administered ION440 in Patients With MECP2 Duplication Syndrome\"<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u0391\u03c2 \u03b4\u03bf\u03cd\u03bc\u03b5 \u03c4\u03b9 \u03c3\u03b7\u03bc\u03b1\u03af\u03bd\u03b5\u03b9 \u03b1\u03c5\u03c4\u03cc.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u0394\u03bf\u03ba\u03b9\u03bc\u03ae \u03c6\u03ac\u03c3\u03b7\u03c2 1-2:<\/strong>&nbsp;\u0397 \u03a6\u03ac\u03c3\u03b7 1 \u03b1\u03bd\u03c4\u03b9\u03c0\u03c1\u03bf\u03c3\u03c9\u03c0\u03b5\u03cd\u03b5\u03b9 \u03c4\u03b7\u03bd \u03c0\u03c1\u03ce\u03c4\u03b7 \u03c6\u03bf\u03c1\u03ac \u03c0\u03bf\u03c5 \u03ad\u03bd\u03b1 \u03c6\u03ac\u03c1\u03bc\u03b1\u03ba\u03bf \u03c7\u03bf\u03c1\u03b7\u03b3\u03b5\u03af\u03c4\u03b1\u03b9 \u03c3\u03b5 \u03b1\u03bd\u03b8\u03c1\u03ce\u03c0\u03bf\u03c5\u03c2 (\u03c3\u03c5\u03c7\u03bd\u03ac \u03b1\u03bd\u03b1\u03c6\u03ad\u03c1\u03b5\u03c4\u03b1\u03b9 \u03c9\u03c2 \u03b4\u03bf\u03ba\u03b9\u03bc\u03ae \"first-in-human\"). \u0397 \u03a6\u03ac\u03c3\u03b7 1 \u03c0\u03c1\u03bf\u03bf\u03c1\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03ba\u03c5\u03c1\u03af\u03c9\u03c2 \u03b3\u03b9\u03b1 \u03c4\u03bf\u03bd \u03c0\u03c1\u03bf\u03c3\u03b4\u03b9\u03bf\u03c1\u03b9\u03c3\u03bc\u03cc \u03c4\u03b7\u03c2 \u03b1\u03c1\u03c7\u03b9\u03ba\u03ae\u03c2 \u03b1\u03c3\u03c6\u03ac\u03bb\u03b5\u03b9\u03b1\u03c2 \u03ba\u03b1\u03b9 \u03b1\u03bd\u03b5\u03ba\u03c4\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1\u03c2 \u03c4\u03bf\u03c5 \u03c5\u03c0\u03cc \u03ad\u03c1\u03b5\u03c5\u03bd\u03b1 \u03c6\u03b1\u03c1\u03bc\u03ac\u03ba\u03bf\u03c5 \u03c3\u03b5 \u03b4\u03b9\u03ac\u03c6\u03bf\u03c1\u03b5\u03c2 \u03b4\u03cc\u03c3\u03b5\u03b9\u03c2, \u03b5\u03af\u03bd\u03b1\u03b9 \u03c3\u03c5\u03bd\u03ae\u03b8\u03c9\u03c2 \u03bc\u03b9\u03ba\u03c1\u03ad\u03c2 \u03ba\u03b1\u03b9 \u03c3\u03c7\u03b5\u03c4\u03b9\u03ba\u03ac \u03b3\u03c1\u03ae\u03b3\u03bf\u03c1\u03b5\u03c2. \u039f\u03b9 \u03b4\u03bf\u03ba\u03b9\u03bc\u03ad\u03c2 \u03c6\u03ac\u03c3\u03b7\u03c2 2 \u03c0\u03b1\u03c1\u03ad\u03c7\u03bf\u03c5\u03bd \u03c0\u03c1\u03cc\u03c3\u03b8\u03b5\u03c4\u03b5\u03c2 \u03b1\u03c0\u03bf\u03b4\u03b5\u03af\u03be\u03b5\u03b9\u03c2 \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd \u03b1\u03c3\u03c6\u03ac\u03bb\u03b5\u03b9\u03b1, \u03bc\u03b5\u03bb\u03b5\u03c4\u03ce\u03bd\u03c4\u03b1\u03c2 \u03c4\u03b7\u03bd \u03b5\u03c0\u03af\u03b4\u03c1\u03b1\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03c5\u03c0\u03cc \u03ad\u03c1\u03b5\u03c5\u03bd\u03b1 \u03c6\u03b1\u03c1\u03bc\u03ac\u03ba\u03bf\u03c5 \u03c3\u03b5 \u03c0\u03b5\u03c1\u03b9\u03c3\u03c3\u03cc\u03c4\u03b5\u03c1\u03bf\u03c5\u03c2 \u03b1\u03bd\u03b8\u03c1\u03ce\u03c0\u03bf\u03c5\u03c2 \u03b3\u03b9\u03b1 \u03bc\u03b5\u03b3\u03b1\u03bb\u03cd\u03c4\u03b5\u03c1\u03bf \u03c7\u03c1\u03bf\u03bd\u03b9\u03ba\u03cc \u03b4\u03b9\u03ac\u03c3\u03c4\u03b7\u03bc\u03b1. \u03a3\u03c5\u03c7\u03bd\u03ac \u03c3\u03c4\u03b9\u03c2 \u03b4\u03bf\u03ba\u03b9\u03bc\u03ad\u03c2 \u03c6\u03ac\u03c3\u03b7\u03c2 2, \u03c3\u03c5\u03bc\u03c0\u03b5\u03c1\u03b9\u03bb\u03b1\u03bc\u03b2\u03b1\u03bd\u03bf\u03bc\u03ad\u03bd\u03bf\u03c5 \u03c4\u03bf\u03c5 ATTUNE, \u03bf\u03b9 \u03b5\u03c1\u03b5\u03c5\u03bd\u03b7\u03c4\u03ad\u03c2 \u03b5\u03c0\u03b9\u03b4\u03b9\u03ce\u03ba\u03bf\u03c5\u03bd \u03b5\u03c0\u03af\u03c3\u03b7\u03c2 \u03bd\u03b1 \u03ba\u03b1\u03c4\u03b1\u03bd\u03bf\u03ae\u03c3\u03bf\u03c5\u03bd \u03c0\u03ce\u03c2 \u03b1\u03bd\u03c4\u03b9\u03b4\u03c1\u03bf\u03cd\u03bd \u03bf\u03b9 \u03ac\u03bd\u03b8\u03c1\u03c9\u03c0\u03bf\u03b9 \u03c3\u03b5 \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03b5\u03c4\u03b9\u03ba\u03ad\u03c2 \u03b4\u03cc\u03c3\u03b5\u03b9\u03c2 \u03c4\u03bf\u03c5 \u03c5\u03c0\u03cc \u03ad\u03c1\u03b5\u03c5\u03bd\u03b1 \u03c6\u03b1\u03c1\u03bc\u03ac\u03ba\u03bf\u03c5. \u0397 \u03b4\u03bf\u03ba\u03b9\u03bc\u03ae ATTUNE \u03b5\u03af\u03bd\u03b1\u03b9 \u03ad\u03bd\u03b1\u03c2 \u03c3\u03c5\u03bd\u03b4\u03c5\u03b1\u03c3\u03bc\u03cc\u03c2 \u03b4\u03bf\u03ba\u03b9\u03bc\u03ce\u03bd \u03c6\u03ac\u03c3\u03b7\u03c2 1 \u03ba\u03b1\u03b9 \u03c6\u03ac\u03c3\u03b7\u03c2 2 \u03bc\u03b1\u03b6\u03af.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u03a4\u03c5\u03c7\u03b1\u03b9\u03bf\u03c0\u03bf\u03b9\u03b7\u03bc\u03ad\u03bd\u03b7, \u03b4\u03b9\u03c0\u03bb\u03ac \u03c4\u03c5\u03c6\u03bb\u03ae, \u03b5\u03bb\u03b5\u03b3\u03c7\u03cc\u03bc\u03b5\u03bd\u03b7 \u03bc\u03b5 \u03b5\u03b9\u03ba\u03bf\u03bd\u03b9\u03ba\u03ae \u03bc\u03ad\u03b8\u03bf\u03b4\u03bf:<\/strong>&nbsp;\u0391\u03c5\u03c4\u03cc \u03c3\u03b7\u03bc\u03b1\u03af\u03bd\u03b5\u03b9 \u03cc\u03c4\u03b9 \u03bf\u03b9 \u03c3\u03c5\u03bc\u03bc\u03b5\u03c4\u03ad\u03c7\u03bf\u03bd\u03c4\u03b5\u03c2 \u03ba\u03b1\u03c4\u03b1\u03bd\u03ad\u03bc\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c4\u03c5\u03c7\u03b1\u03af\u03b1 \u03bd\u03b1 \u03bb\u03ac\u03b2\u03bf\u03c5\u03bd \u03b5\u03af\u03c4\u03b5 \u03c4\u03b7 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03bc\u03b5 ION440 \u03b5\u03af\u03c4\u03b5 \u03bc\u03b9\u03b1 \u03b5\u03b9\u03ba\u03bf\u03bd\u03b9\u03ba\u03ae \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 (\u03c7\u03c9\u03c1\u03af\u03c2 \u03ad\u03bd\u03b5\u03c3\u03b7 ION440 \u03b1\u03bb\u03bb\u03ac \u03bc\u03b5 \u03c4\u03b7\u03bd \u03af\u03b4\u03b9\u03b1 \u03b4\u03b9\u03b1\u03b4\u03b9\u03ba\u03b1\u03c3\u03af\u03b1 \u03ba\u03b1\u03c4\u03b1\u03c3\u03c4\u03bf\u03bb\u03ae\u03c2 \u03cc\u03c0\u03c9\u03c2 \u03c3\u03c4\u03b7\u03bd \u03bf\u03bc\u03ac\u03b4\u03b1 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1\u03c2) \u03c3\u03b5 \u03b1\u03bd\u03b1\u03bb\u03bf\u03b3\u03af\u03b1 3:1 (3 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03c0\u03bf\u03c5 \u03bb\u03b1\u03bc\u03b2\u03ac\u03bd\u03bf\u03c5\u03bd ION440 \u03b3\u03b9\u03b1 1 \u03b1\u03c3\u03b8\u03b5\u03bd\u03ae \u03c0\u03bf\u03c5 \u03b4\u03b5\u03bd \u03bb\u03b1\u03bc\u03b2\u03ac\u03bd\u03b5\u03b9 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1). \u039f\u03cd\u03c4\u03b5 \u03bf\u03b9 \u03c3\u03c5\u03bc\u03bc\u03b5\u03c4\u03ad\u03c7\u03bf\u03bd\u03c4\u03b5\u03c2 \u03bf\u03cd\u03c4\u03b5 \u03bf\u03b9 \u03b5\u03c1\u03b5\u03c5\u03bd\u03b7\u03c4\u03ad\u03c2 \u03b3\u03bd\u03c9\u03c1\u03af\u03b6\u03bf\u03c5\u03bd \u03c0\u03bf\u03b9\u03bf\u03c2 \u03bb\u03b1\u03bc\u03b2\u03ac\u03bd\u03b5\u03b9 \u03c4\u03b7\u03bd \u03c0\u03c1\u03b1\u03b3\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03ba\u03b1\u03b9 \u03c0\u03bf\u03b9\u03bf\u03c2 \u03c4\u03b7\u03bd \u03b5\u03b9\u03ba\u03bf\u03bd\u03b9\u03ba\u03ae.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u0388\u03bd\u03b1 \u03c3\u03ba\u03ad\u03bb\u03bf\u03c2 \u03b5\u03bb\u03ad\u03b3\u03c7\u03bf\u03c5 \u03c7\u03c1\u03b7\u03c3\u03b9\u03bc\u03bf\u03c0\u03bf\u03b9\u03b5\u03af\u03c4\u03b1\u03b9 \u03c3\u03c5\u03c7\u03bd\u03ac \u03cc\u03c4\u03b1\u03bd (1) \u03c4\u03b1 \u03c3\u03b7\u03bc\u03b5\u03af\u03b1 \u03ba\u03b1\u03b9 \u03c4\u03b1 \u03c3\u03c5\u03bc\u03c0\u03c4\u03ce\u03bc\u03b1\u03c4\u03b1 \u03c4\u03b7\u03c2 \u03bd\u03cc\u03c3\u03bf\u03c5 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03b5\u03c4\u03b9\u03ba\u03ac \u03b1\u03c0\u03cc \u03ac\u03c4\u03bf\u03bc\u03bf \u03c3\u03b5 \u03ac\u03c4\u03bf\u03bc\u03bf (2) \u03c5\u03c0\u03ac\u03c1\u03c7\u03b5\u03b9 \u03c0\u03b5\u03c1\u03b9\u03bf\u03c1\u03b9\u03c3\u03bc\u03ad\u03bd\u03bf \u03c6\u03c5\u03c3\u03b9\u03ba\u03cc \u03b9\u03c3\u03c4\u03bf\u03c1\u03b9\u03ba\u03cc \u03c3\u03c4\u03bf\u03bd \u03c3\u03c5\u03b3\u03ba\u03b5\u03ba\u03c1\u03b9\u03bc\u03ad\u03bd\u03bf \u03c0\u03bb\u03b7\u03b8\u03c5\u03c3\u03bc\u03cc \u03c0\u03bf\u03c5 \u03b4\u03b9\u03b5\u03c1\u03b5\u03c5\u03bd\u03ac\u03c4\u03b1\u03b9 \u03c3\u03c4\u03b7 \u03b4\u03bf\u03ba\u03b9\u03bc\u03ae (3) \u03bf\u03b9 \u03c3\u03c4\u03cc\u03c7\u03bf\u03b9 \u03c4\u03b7\u03c2 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae\u03c2 \u03b4\u03bf\u03ba\u03b9\u03bc\u03ae\u03c2 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b1\u03c0\u03bf\u03c4\u03c5\u03c0\u03c9\u03b8\u03bf\u03cd\u03bd \u03bc\u03b5 \u03c4\u03c1\u03cc\u03c0\u03bf \u03c0\u03bf\u03c5 \u03b8\u03b1 \u03bc\u03c0\u03bf\u03c1\u03bf\u03cd\u03c3\u03b5 \u03bd\u03b1 \u03b8\u03b5\u03c9\u03c1\u03b7\u03b8\u03b5\u03af \u03c5\u03c0\u03bf\u03ba\u03b5\u03b9\u03bc\u03b5\u03bd\u03b9\u03ba\u03cc\u03c2 \u03ae \u03bc\u03b5\u03c1\u03bf\u03bb\u03b7\u03c0\u03c4\u03b9\u03ba\u03cc\u03c2 \u03ba\u03b1\u03b9 (4) \u03c5\u03c0\u03ac\u03c1\u03c7\u03b5\u03b9 \u03c0\u03b5\u03c1\u03b9\u03bf\u03c1\u03b9\u03c3\u03bc\u03ad\u03bd\u03b7 \u03ba\u03b1\u03c4\u03b1\u03bd\u03cc\u03b7\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03c4\u03c1\u03cc\u03c0\u03bf\u03c5 \u03bc\u03b5 \u03c4\u03bf\u03bd \u03bf\u03c0\u03bf\u03af\u03bf \u03bf \u03c3\u03c5\u03b3\u03ba\u03b5\u03ba\u03c1\u03b9\u03bc\u03ad\u03bd\u03bf\u03c2 \u03c0\u03bb\u03b7\u03b8\u03c5\u03c3\u03bc\u03cc\u03c2 \u03c4\u03c9\u03bd \u03b5\u03b3\u03b3\u03b5\u03b3\u03c1\u03b1\u03bc\u03bc\u03ad\u03bd\u03c9\u03bd \u03b1\u03c4\u03cc\u03bc\u03c9\u03bd \u03b8\u03b1 \u03b1\u03bd\u03c4\u03b1\u03c0\u03bf\u03ba\u03c1\u03b9\u03b8\u03b5\u03af \u03c3\u03b5 \u03c3\u03c5\u03b3\u03ba\u03b5\u03ba\u03c1\u03b9\u03bc\u03ad\u03bd\u03bf\u03c5\u03c2 \u03c4\u03cd\u03c0\u03bf\u03c5\u03c2 \u03b4\u03b9\u03b1\u03b4\u03b9\u03ba\u03b1\u03c3\u03b9\u03ce\u03bd, \u03cc\u03c0\u03c9\u03c2 \u03b7 \u03ba\u03b1\u03c4\u03b1\u03c3\u03c4\u03bf\u03bb\u03ae \u03ba\u03b1\u03b9 \u03b7 \u03bf\u03c3\u03c6\u03c5\u03bf\u03bd\u03c9\u03c4\u03b9\u03b1\u03af\u03b1 \u03c0\u03b1\u03c1\u03b1\u03ba\u03ad\u03bd\u03c4\u03b7\u03c3\u03b7 \u03c0\u03bf\u03c5 \u03b1\u03c0\u03b1\u03b9\u03c4\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 \u03b3\u03b9\u03b1 \u03c4\u03b7 \u03c7\u03bf\u03c1\u03ae\u03b3\u03b7\u03c3\u03b7 \u03c4\u03bf\u03c5 ION440.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u0394\u03cc\u03c3\u03b7 \u03c0\u03bf\u03bb\u03bb\u03b1\u03c0\u03bb\u03ae\u03c2 \u03b1\u03bd\u03cc\u03b4\u03bf\u03c5 (MAD):<\/strong>&nbsp;\u0391\u03c5\u03c4\u03cc \u03c3\u03b7\u03bc\u03b1\u03af\u03bd\u03b5\u03b9 \u03cc\u03c4\u03b9 \u03bf\u03b9 \u03b5\u03c1\u03b5\u03c5\u03bd\u03b7\u03c4\u03ad\u03c2 \u03c7\u03bf\u03c1\u03b7\u03b3\u03bf\u03cd\u03bd \u03b4\u03b9\u03b1\u03b4\u03bf\u03c7\u03b9\u03ba\u03ac \u03b1\u03c5\u03be\u03b1\u03bd\u03cc\u03bc\u03b5\u03bd\u03b5\u03c2 \u03b4\u03cc\u03c3\u03b5\u03b9\u03c2 \u03c4\u03bf\u03c5 \u03b5\u03c1\u03b5\u03c5\u03bd\u03b7\u03c4\u03b9\u03ba\u03bf\u03cd \u03c6\u03b1\u03c1\u03bc\u03ac\u03ba\u03bf\u03c5 \u03c3\u03b5 \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03b5\u03c4\u03b9\u03ba\u03ad\u03c2 \u03bf\u03bc\u03ac\u03b4\u03b5\u03c2 \u03c3\u03c5\u03bc\u03bc\u03b5\u03c4\u03b5\u03c7\u03cc\u03bd\u03c4\u03c9\u03bd \u03b3\u03b9\u03b1 \u03bd\u03b1 \u03b4\u03bf\u03c5\u03bd \u03c0\u03cc\u03c3\u03b7 \u03c0\u03bf\u03c3\u03cc\u03c4\u03b7\u03c4\u03b1 \u03c4\u03bf\u03c5 \u03c6\u03b1\u03c1\u03bc\u03ac\u03ba\u03bf\u03c5 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03c7\u03bf\u03c1\u03b7\u03b3\u03b7\u03b8\u03b5\u03af \u03bc\u03b5 \u03b1\u03c3\u03c6\u03ac\u03bb\u03b5\u03b9\u03b1.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u039c\u03ad\u03c1\u03bf\u03c2 1 \u03ba\u03b1\u03b9 \u03bc\u03ad\u03c1\u03bf\u03c2 2 \u03c4\u03b7\u03c2 \u03b4\u03b9\u03b1\u03b4\u03b9\u03ba\u03b1\u03c3\u03af\u03b1\u03c2:<\/strong>&nbsp;\u03a4\u03bf ATTUNE \u03c7\u03c9\u03c1\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03c3\u03b5 \u03b4\u03cd\u03bf \u03bc\u03ad\u03c1\u03b7. \u038c\u03bb\u03b1 \u03c4\u03b1 \u03ac\u03c4\u03bf\u03bc\u03b1 \u03c0\u03bf\u03c5 \u03b3\u03af\u03bd\u03bf\u03bd\u03c4\u03b1\u03b9 \u03b4\u03b5\u03ba\u03c4\u03ac \u03c3\u03c4\u03b7 \u03b4\u03bf\u03ba\u03b9\u03bc\u03ae \u03b8\u03b1 \u03be\u03b5\u03ba\u03b9\u03bd\u03ae\u03c3\u03bf\u03c5\u03bd \u03b1\u03c0\u03cc \u03c4\u03bf \u039c\u03ad\u03c1\u03bf\u03c2 1. \u03a3\u03c4\u03bf \u039c\u03ad\u03c1\u03bf\u03c2 1, 75% \u03c4\u03c9\u03bd \u03c3\u03c5\u03bc\u03bc\u03b5\u03c4\u03b5\u03c7\u03cc\u03bd\u03c4\u03c9\u03bd \u03b8\u03b1 \u03bb\u03ac\u03b2\u03bf\u03c5\u03bd ION440 \u03ba\u03b1\u03b9 25% \u03b8\u03b1 \u03bb\u03ac\u03b2\u03bf\u03c5\u03bd \u03b5\u03b9\u03ba\u03bf\u03bd\u03b9\u03ba\u03ae \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03b3\u03b9\u03b1 \u03c0\u03b5\u03c1\u03af\u03c0\u03bf\u03c5 36 \u03b5\u03b2\u03b4\u03bf\u03bc\u03ac\u03b4\u03b5\u03c2. \u0391\u03c6\u03bf\u03cd \u03b7 Ionis \u03bf\u03bb\u03bf\u03ba\u03bb\u03b7\u03c1\u03ce\u03c3\u03b5\u03b9 \u03b5\u03c0\u03b9\u03c4\u03c5\u03c7\u03ce\u03c2 \u03ad\u03bd\u03b1\u03bd \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf \u03b1\u03c3\u03c6\u03ac\u03bb\u03b5\u03b9\u03b1\u03c2 \u03ba\u03b1\u03c4\u03ac \u03c4\u03b7 \u03b4\u03b9\u03ac\u03c1\u03ba\u03b5\u03b9\u03b1 \u03c4\u03bf\u03c5 \u03c0\u03c1\u03ce\u03b9\u03bc\u03bf\u03c5 \u03bc\u03ad\u03c1\u03bf\u03c5\u03c2 \u03c4\u03b7\u03c2 \u03b4\u03bf\u03ba\u03b9\u03bc\u03ae\u03c2, \u03bf\u03b9 \u03c3\u03c5\u03bc\u03bc\u03b5\u03c4\u03ad\u03c7\u03bf\u03bd\u03c4\u03b5\u03c2 \u03c0\u03bf\u03c5 \u03bf\u03bb\u03bf\u03ba\u03bb\u03ae\u03c1\u03c9\u03c3\u03b1\u03bd \u03c4\u03bf \u039c\u03ad\u03c1\u03bf\u03c2 1 \u03b8\u03b1 \u03ad\u03c7\u03bf\u03c5\u03bd \u03c4\u03b7\u03bd \u03b5\u03c5\u03ba\u03b1\u03b9\u03c1\u03af\u03b1 \u03bd\u03b1 \u03bb\u03ac\u03b2\u03bf\u03c5\u03bd \u03c4\u03bf ION440 \u03b3\u03b9\u03b1 \u03ad\u03c9\u03c2 \u03ba\u03b1\u03b9 156 \u03b5\u03b2\u03b4\u03bf\u03bc\u03ac\u03b4\u03b5\u03c2 \u03ba\u03b1\u03c4\u03ac \u03c4\u03b7 \u03b4\u03b9\u03ac\u03c1\u03ba\u03b5\u03b9\u03b1 \u03c4\u03b7\u03c2 \u03c0\u03b1\u03c1\u03ac\u03c4\u03b1\u03c3\u03b7\u03c2 \u03b1\u03bd\u03bf\u03b9\u03ba\u03c4\u03ae\u03c2 \u03b5\u03c0\u03b9\u03c3\u03ae\u03bc\u03b1\u03bd\u03c3\u03b7\u03c2 (LTE), \u03b3\u03bd\u03c9\u03c3\u03c4\u03ae\u03c2 \u03c9\u03c2 \u039c\u03ad\u03c1\u03bf\u03c2 2.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u0391\u03c3\u03c6\u03ac\u03bb\u03b5\u03b9\u03b1, \u03b1\u03bd\u03b5\u03ba\u03c4\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1, \u03c6\u03b1\u03c1\u03bc\u03b1\u03ba\u03bf\u03ba\u03b9\u03bd\u03b7\u03c4\u03b9\u03ba\u03ae, \u03c6\u03b1\u03c1\u03bc\u03b1\u03ba\u03bf\u03b4\u03c5\u03bd\u03b1\u03bc\u03b9\u03ba\u03ae:&nbsp;<\/strong>\u0391\u03c5\u03c4\u03ac \u03ba\u03b1\u03b8\u03bf\u03c1\u03af\u03b6\u03bf\u03c5\u03bd \u03c4\u03bf\u03c5\u03c2 \u03c3\u03c4\u03cc\u03c7\u03bf\u03c5\u03c2 \u03c4\u03b7\u03c2 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b7\u03c2 \u03c6\u03ac\u03c3\u03b7\u03c2 1-2 \u03b3\u03b9\u03b1 \u03c4\u03bf ION440, \u03b1\u03be\u03b9\u03bf\u03bb\u03bf\u03b3\u03ce\u03bd\u03c4\u03b1\u03c2 \u03b5\u03ac\u03bd \u03ae \u03c0\u03bf\u03b9\u03b5\u03c2 \u03c0\u03b1\u03c1\u03b5\u03bd\u03ad\u03c1\u03b3\u03b5\u03b9\u03b5\u03c2 \u03bc\u03c0\u03bf\u03c1\u03bf\u03cd\u03bd \u03bd\u03b1 \u03c0\u03b1\u03c1\u03b1\u03c4\u03b7\u03c1\u03b7\u03b8\u03bf\u03cd\u03bd \u03bc\u03b5\u03c4\u03ac \u03c4\u03b7 \u03c7\u03bf\u03c1\u03ae\u03b3\u03b7\u03c3\u03b7 \u03c4\u03bf\u03c5 ION440, \u03c4\u03b9 \u03ba\u03ac\u03bd\u03b5\u03b9 \u03bf \u03bf\u03c1\u03b3\u03b1\u03bd\u03b9\u03c3\u03bc\u03cc\u03c2 \u03c3\u03c4\u03bf ION440, \u03c4\u03b9 \u03ba\u03ac\u03bd\u03b5\u03b9 \u03c4\u03bf ION440 \u03c3\u03c4\u03bf\u03bd \u03b1\u03bd\u03b8\u03c1\u03ce\u03c0\u03b9\u03bd\u03bf \u03bf\u03c1\u03b3\u03b1\u03bd\u03b9\u03c3\u03bc\u03cc.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u039a\u03c1\u03b9\u03c4\u03ae\u03c1\u03b9\u03b1 \u03ad\u03bd\u03c4\u03b1\u03be\u03b7\u03c2 \u03ba\u03b1\u03b9 \u03b1\u03c0\u03bf\u03ba\u03bb\u03b5\u03b9\u03c3\u03bc\u03bf\u03cd:<\/strong>&nbsp;\u0391\u03c5\u03c4\u03bf\u03af \u03b5\u03af\u03bd\u03b1\u03b9 \u03bf\u03b9 \u03ba\u03b1\u03bd\u03cc\u03bd\u03b5\u03c2 \u03c0\u03bf\u03c5 \u03b1\u03c0\u03bf\u03c6\u03b1\u03c3\u03af\u03b6\u03bf\u03c5\u03bd \u03c0\u03bf\u03b9\u03bf\u03c2 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03c3\u03c5\u03bc\u03bc\u03b5\u03c4\u03ac\u03c3\u03c7\u03b5\u03b9 \u03c3\u03c4\u03b7\u03bd \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03b4\u03bf\u03ba\u03b9\u03bc\u03ae. \u0393\u03b9\u03b1 \u03c0\u03b1\u03c1\u03ac\u03b4\u03b5\u03b9\u03b3\u03bc\u03b1, \u03c3\u03b5 \u03b1\u03c5\u03c4\u03ae \u03c4\u03b7 \u03b4\u03bf\u03ba\u03b9\u03bc\u03ae, \u03bf\u03b9 \u03c3\u03c5\u03bc\u03bc\u03b5\u03c4\u03ad\u03c7\u03bf\u03bd\u03c4\u03b5\u03c2 \u03c0\u03c1\u03ad\u03c0\u03b5\u03b9 \u03bd\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03ac\u03bd\u03b4\u03c1\u03b5\u03c2, \u03b7\u03bb\u03b9\u03ba\u03af\u03b1\u03c2 2 \u03ad\u03c9\u03c2 65 \u03b5\u03c4\u03ce\u03bd, \u03bd\u03b1 \u03ad\u03c7\u03bf\u03c5\u03bd \u03b5\u03c0\u03b9\u03b2\u03b5\u03b2\u03b1\u03b9\u03c9\u03bc\u03ad\u03bd\u03b7 \u03b4\u03b9\u03ac\u03b3\u03bd\u03c9\u03c3\u03b7 MDS \u03ba\u03b1\u03b9 \u03bd\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c3\u03b5 \u03b8\u03ad\u03c3\u03b7 \u03bd\u03b1 \u03bf\u03bb\u03bf\u03ba\u03bb\u03b7\u03c1\u03ce\u03c3\u03bf\u03c5\u03bd \u03cc\u03bb\u03b5\u03c2 \u03c4\u03b9\u03c2 \u03b4\u03b9\u03b1\u03b4\u03b9\u03ba\u03b1\u03c3\u03af\u03b5\u03c2 \u03c4\u03b7\u03c2 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b7\u03c2. \u03a5\u03c0\u03ac\u03c1\u03c7\u03bf\u03c5\u03bd \u03b5\u03c0\u03af\u03c3\u03b7\u03c2 \u03bf\u03c1\u03b9\u03c3\u03bc\u03ad\u03bd\u03b5\u03c2 \u03ba\u03b1\u03c4\u03b1\u03c3\u03c4\u03ac\u03c3\u03b5\u03b9\u03c2 \u03c0\u03bf\u03c5 \u03b8\u03b1 \u03b5\u03bc\u03c0\u03cc\u03b4\u03b9\u03b6\u03b1\u03bd \u03ba\u03ac\u03c0\u03bf\u03b9\u03bf\u03bd \u03bd\u03b1 \u03c3\u03c5\u03bc\u03bc\u03b5\u03c4\u03ac\u03c3\u03c7\u03b5\u03b9, \u03cc\u03c0\u03c9\u03c2 \u03c4\u03bf \u03bd\u03b1 \u03ad\u03c7\u03b5\u03b9 \u03bc\u03b9\u03b1 \u03c3\u03cd\u03bd\u03b8\u03b5\u03c4\u03b7 \u03bc\u03bf\u03c1\u03c6\u03ae MDS, \u03bd\u03b1 \u03ad\u03c7\u03b5\u03b9 \u03bf\u03c1\u03b9\u03c3\u03bc\u03ad\u03bd\u03b5\u03c2 \u03c0\u03b1\u03b8\u03ae\u03c3\u03b5\u03b9\u03c2 \u03ae \u03bd\u03b1 \u03c5\u03c0\u03bf\u03b2\u03ac\u03bb\u03bb\u03b5\u03c4\u03b1\u03b9 \u03c3\u03b5 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03bc\u03b5 \u03bf\u03c1\u03b9\u03c3\u03bc\u03ad\u03bd\u03b1 \u03ac\u03bb\u03bb\u03b1 \u03c6\u03ac\u03c1\u03bc\u03b1\u03ba\u03b1.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u0395\u03af\u03bd\u03b1\u03b9 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03cc \u03bd\u03b1 \u03c3\u03b7\u03bc\u03b5\u03b9\u03c9\u03b8\u03b5\u03af \u03cc\u03c4\u03b9 \u03b7 \u03c3\u03c5\u03bc\u03bc\u03b5\u03c4\u03bf\u03c7\u03ae \u03c3\u03b5 \u03bc\u03b9\u03b1 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03b4\u03bf\u03ba\u03b9\u03bc\u03ae \u03b5\u03af\u03bd\u03b1\u03b9 \u03b5\u03b8\u03b5\u03bb\u03bf\u03bd\u03c4\u03b9\u03ba\u03ae \u03ba\u03b1\u03b9 \u03bf\u03b9 \u03bf\u03b9\u03ba\u03bf\u03b3\u03ad\u03bd\u03b5\u03b9\u03b5\u03c2 \u03bc\u03c0\u03bf\u03c1\u03bf\u03cd\u03bd \u03bd\u03b1 \u03c4\u03b7\u03bd \u03b1\u03c0\u03bf\u03c3\u03cd\u03c1\u03bf\u03c5\u03bd \u03b1\u03bd\u03ac \u03c0\u03ac\u03c3\u03b1 \u03c3\u03c4\u03b9\u03b3\u03bc\u03ae, \u03b5\u03ac\u03bd \u03b8\u03b5\u03c9\u03c1\u03bf\u03cd\u03bd \u03cc\u03c4\u03b9 \u03b4\u03b5\u03bd \u03b5\u03af\u03bd\u03b1\u03b9 \u03c0\u03c1\u03bf\u03c2 \u03c4\u03bf \u03c3\u03c5\u03bc\u03c6\u03ad\u03c1\u03bf\u03bd \u03c4\u03bf\u03c5 \u03c0\u03b1\u03b9\u03b4\u03b9\u03bf\u03cd \u03c4\u03bf\u03c5\u03c2.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>\u0388\u03bd\u03b1\u03c1\u03be\u03b7 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b7\u03c2:<\/strong>&nbsp;\u0397 \u03b5\u03ba\u03c4\u03b9\u03bc\u03ce\u03bc\u03b5\u03bd\u03b7 \u03b7\u03bc\u03b5\u03c1\u03bf\u03bc\u03b7\u03bd\u03af\u03b1 \u03ad\u03bd\u03b1\u03c1\u03be\u03b7\u03c2 \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03af\u03b1\u03c2 \u03c4\u03bf\u03c5 ATTUNE \u03b5\u03af\u03bd\u03b1\u03b9 \u03bf \u0391\u03cd\u03b3\u03bf\u03c5\u03c3\u03c4\u03bf\u03c2 \u03c4\u03bf\u03c5 2024. \u03a9\u03c3\u03c4\u03cc\u03c3\u03bf, \u03b1\u03c5\u03c4\u03cc \u03c4\u03bf \u03c7\u03c1\u03bf\u03bd\u03bf\u03b4\u03b9\u03ac\u03b3\u03c1\u03b1\u03bc\u03bc\u03b1 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b1\u03bb\u03bb\u03ac\u03be\u03b5\u03b9 \u03b1\u03bd\u03ac\u03bb\u03bf\u03b3\u03b1 \u03bc\u03b5 \u03c4\u03b1 \u03c1\u03c5\u03b8\u03bc\u03b9\u03c3\u03c4\u03b9\u03ba\u03ac \u03b2\u03ae\u03bc\u03b1\u03c4\u03b1, \u03cc\u03c0\u03c9\u03c2 \u03b7 \u03ad\u03b3\u03ba\u03c1\u03b9\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03b5\u03c0\u03b9\u03c4\u03c1\u03bf\u03c0\u03ae\u03c2 \u03b4\u03b5\u03bf\u03bd\u03c4\u03bf\u03bb\u03bf\u03b3\u03af\u03b1\u03c2, \u03bf\u03b9 \u03c5\u03c0\u03bf\u03b3\u03c1\u03b1\u03c6\u03ad\u03c2 \u03c3\u03c5\u03bc\u03b2\u03ac\u03c3\u03b5\u03c9\u03bd \u03ba\u03b1\u03b9 \u03ac\u03bb\u03bb\u03b5\u03c2 \u03b5\u03b3\u03ba\u03c1\u03af\u03c3\u03b5\u03b9\u03c2 \u03c0\u03bf\u03c5 \u03b1\u03c0\u03b1\u03b9\u03c4\u03bf\u03cd\u03bd\u03c4\u03b1\u03b9 \u03c3\u03b5 \u03ba\u03ac\u03b8\u03b5 \u03bd\u03bf\u03c3\u03bf\u03ba\u03bf\u03bc\u03b5\u03af\u03bf \u03cc\u03c0\u03bf\u03c5 \u03b8\u03b1 \u03b4\u03b9\u03b5\u03be\u03b1\u03c7\u03b8\u03b5\u03af \u03b7 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b7. \u0397 \u03b5\u03b3\u03b3\u03c1\u03b1\u03c6\u03ae \u03b1\u03c3\u03b8\u03b5\u03bd\u03ce\u03bd \u03b8\u03b1 \u03be\u03b5\u03ba\u03b9\u03bd\u03ae\u03c3\u03b5\u03b9 \u03bc\u03cc\u03bb\u03b9\u03c2 \u03c5\u03c0\u03bf\u03b3\u03c1\u03b1\u03c6\u03bf\u03cd\u03bd \u03cc\u03bb\u03b5\u03c2 \u03bf\u03b9 \u03b5\u03b3\u03ba\u03c1\u03af\u03c3\u03b5\u03b9\u03c2 \u03c4\u03cc\u03c3\u03bf \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd Ionis \u03cc\u03c3\u03bf \u03ba\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03bf \u03bd\u03bf\u03c3\u03bf\u03ba\u03bf\u03bc\u03b5\u03af\u03bf.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u039d\u03b1 \u03b8\u03c5\u03bc\u03ac\u03c3\u03c4\u03b5 \u03cc\u03c4\u03b9 \u03bf\u03b9 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ad\u03c2 \u03b4\u03bf\u03ba\u03b9\u03bc\u03ad\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b1\u03c0\u03b1\u03c1\u03b1\u03af\u03c4\u03b7\u03c4\u03b5\u03c2 \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd \u03c0\u03c1\u03cc\u03bf\u03b4\u03bf \u03c4\u03b7\u03c2 \u03b9\u03b1\u03c4\u03c1\u03b9\u03ba\u03ae\u03c2 \u03b3\u03bd\u03ce\u03c3\u03b7\u03c2 \u03ba\u03b1\u03b9 \u03c4\u03b7\u03bd \u03b5\u03be\u03b5\u03cd\u03c1\u03b5\u03c3\u03b7 \u03bd\u03ad\u03c9\u03bd \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03b9\u03ce\u03bd \u03ba\u03b1\u03b9 \u03c0\u03c1\u03bf\u03c3\u03c6\u03ad\u03c1\u03bf\u03c5\u03bd \u03b5\u03bb\u03c0\u03af\u03b4\u03b1 \u03c3\u03c4\u03b1 \u03ac\u03c4\u03bf\u03bc\u03b1 \u03ba\u03b1\u03b9 \u03c4\u03b9\u03c2 \u03bf\u03b9\u03ba\u03bf\u03b3\u03ad\u03bd\u03b5\u03b9\u03b5\u03c2 \u03c0\u03bf\u03c5 \u03c0\u03ac\u03c3\u03c7\u03bf\u03c5\u03bd \u03b1\u03c0\u03cc \u03c3\u03c0\u03ac\u03bd\u03b9\u03b5\u03c2 \u03b1\u03c3\u03b8\u03ad\u03bd\u03b5\u03b9\u03b5\u03c2.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u03a4\u03bf ION440 \u03b5\u03af\u03bd\u03b1\u03b9 \u03ad\u03bd\u03b1 \u03b5\u03c1\u03b5\u03c5\u03bd\u03b7\u03c4\u03b9\u03ba\u03cc \u03c6\u03ac\u03c1\u03bc\u03b1\u03ba\u03bf \u03ba\u03b1\u03b9 \u03b4\u03b5\u03bd \u03ad\u03c7\u03b5\u03b9 \u03b5\u03b3\u03ba\u03c1\u03b9\u03b8\u03b5\u03af \u03bd\u03b1 \u03ba\u03c5\u03ba\u03bb\u03bf\u03c6\u03bf\u03c1\u03ae\u03c3\u03b5\u03b9 \u03c3\u03c4\u03b7\u03bd \u03b1\u03b3\u03bf\u03c1\u03ac \u03c9\u03c2 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03b3\u03b9\u03b1 \u03bf\u03c0\u03bf\u03b9\u03b1\u03b4\u03ae\u03c0\u03bf\u03c4\u03b5 \u03b4\u03b9\u03b1\u03c4\u03b1\u03c1\u03b1\u03c7\u03ae, \u03c3\u03c5\u03bc\u03c0\u03b5\u03c1\u03b9\u03bb\u03b1\u03bc\u03b2\u03b1\u03bd\u03bf\u03bc\u03ad\u03bd\u03bf\u03c5 \u03c4\u03bf\u03c5 MDS, \u03c3\u03b5 \u03ba\u03b1\u03bc\u03af\u03b1 \u03c7\u03ce\u03c1\u03b1. \u03a4\u03b1 \u03ac\u03c4\u03bf\u03bc\u03b1 \u03bc\u03b5 \u03b5\u03c1\u03c9\u03c4\u03ae\u03c3\u03b5\u03b9\u03c2 \u03c3\u03c7\u03b5\u03c4\u03b9\u03ba\u03ac \u03bc\u03b5 \u03c4\u03b9\u03c2 \u03b1\u03bb\u03bb\u03b1\u03b3\u03ad\u03c2 \u03c3\u03c4\u03b7\u03bd \u03c5\u03b3\u03b5\u03af\u03b1 \u03c4\u03bf\u03c5\u03c2 \u03ba\u03b1\u03b9 \u03c4\u03b7\u03bd \u03c5\u03b3\u03b5\u03b9\u03bf\u03bd\u03bf\u03bc\u03b9\u03ba\u03ae \u03c4\u03bf\u03c5\u03c2 \u03c0\u03b5\u03c1\u03af\u03b8\u03b1\u03bb\u03c8\u03b7 \u03c3\u03c5\u03bd\u03bf\u03bb\u03b9\u03ba\u03ac \u03b8\u03b1 \u03c0\u03c1\u03ad\u03c0\u03b5\u03b9 \u03bd\u03b1 \u03bc\u03b9\u03bb\u03ae\u03c3\u03bf\u03c5\u03bd \u03bc\u03b5 \u03c4\u03bf\u03bd \u03c0\u03ac\u03c1\u03bf\u03c7\u03bf \u03c5\u03b3\u03b5\u03b9\u03bf\u03bd\u03bf\u03bc\u03b9\u03ba\u03ae\u03c2 \u03c0\u03b5\u03c1\u03af\u03b8\u03b1\u03bb\u03c8\u03b7\u03c2.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u039c\u03b5\u03af\u03bd\u03b5\u03c4\u03b5 \u03c3\u03c5\u03bd\u03c4\u03bf\u03bd\u03b9\u03c3\u03bc\u03ad\u03bd\u03bf\u03b9 \u03b3\u03b9\u03b1 \u03c4\u03bf \u03b4\u03b9\u03b1\u03b4\u03b9\u03ba\u03c4\u03c5\u03b1\u03ba\u03cc \u03bc\u03b1\u03c2 \u03c3\u03b5\u03bc\u03b9\u03bd\u03ac\u03c1\u03b9\u03bf \u03c3\u03c7\u03b5\u03c4\u03b9\u03ba\u03ac \u03bc\u03b5 \u03c4\u03b9\u03c2 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ad\u03c2 \u03b4\u03bf\u03ba\u03b9\u03bc\u03ad\u03c2 \u03ba\u03b1\u03b9 \u03c4\u03bf ATTUNE, \u03c4\u03bf \u03bf\u03c0\u03bf\u03af\u03bf \u03b1\u03bd\u03b1\u03bc\u03ad\u03bd\u03b5\u03c4\u03b1\u03b9 \u03bd\u03b1 \u03ba\u03c5\u03ba\u03bb\u03bf\u03c6\u03bf\u03c1\u03ae\u03c3\u03b5\u03b9 \u03bc\u03ad\u03c7\u03c1\u03b9 \u03c4\u03bf \u03c4\u03ad\u03bb\u03bf\u03c2 \u03a3\u03b5\u03c0\u03c4\u03b5\u03bc\u03b2\u03c1\u03af\u03bf\u03c5 2024.<\/p>\n\n\n\n<div class=\"wp-block-buttons is-layout-flex wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button\"><a class=\"wp-block-button__link wp-element-button\" rel=\"https:\/\/clinicaltrials.gov\/study\/NCT06430385?cond=Mecp2%20Duplication%20Syndrome&amp;rank=2\">\u03a3\u03c4\u03bf clinicaltrials.gov<\/a><\/div>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>Written by David and verified by Ionis Following Ionis\u2019 recent announcement about the upcoming clinical trial, we aim to provide a clearer understanding of this trial. It is especially important for families considering enrolling their child to know what a clinical trial is, particularly in the context of rare diseases like MECP2 Duplication Syndrome (MDS). [&hellip;]<\/p>\n","protected":false},"author":73,"featured_media":1409,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_jf_save_progress":"","footnotes":""},"categories":[11,10,9],"tags":[],"class_list":["post-1400","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-aso","category-cure","category-research"],"_links":{"self":[{"href":"https:\/\/remeds.org\/el\/wp-json\/wp\/v2\/posts\/1400","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/remeds.org\/el\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/remeds.org\/el\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/remeds.org\/el\/wp-json\/wp\/v2\/users\/73"}],"replies":[{"embeddable":true,"href":"https:\/\/remeds.org\/el\/wp-json\/wp\/v2\/comments?post=1400"}],"version-history":[{"count":1,"href":"https:\/\/remeds.org\/el\/wp-json\/wp\/v2\/posts\/1400\/revisions"}],"predecessor-version":[{"id":1401,"href":"https:\/\/remeds.org\/el\/wp-json\/wp\/v2\/posts\/1400\/revisions\/1401"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/remeds.org\/el\/wp-json\/wp\/v2\/media\/1409"}],"wp:attachment":[{"href":"https:\/\/remeds.org\/el\/wp-json\/wp\/v2\/media?parent=1400"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/remeds.org\/el\/wp-json\/wp\/v2\/categories?post=1400"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/remeds.org\/el\/wp-json\/wp\/v2\/tags?post=1400"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}